Dependence between LD50 for Rodents and LC50 for Adult Fish and Fish Embryos
- 作者: Zolotarev K.1, Belyaeva N.1, Mikhailov A.1, Mikhailova M.1
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隶属关系:
- V. N. Orekhovich Research Institute of Biomedical Chemistry
- 期: 卷 162, 编号 4 (2017)
- 页面: 445-450
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238288
- DOI: https://doi.org/10.1007/s10517-017-3636-y
- ID: 238288
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详细
We revealed empirical dependences between common logarithm of a ratio of rat oral LD50 to LCa50 for adult fish and lgP for 50 different chemicals; and common logarithm of a ratio of the oral LD50 in rodents to LCe50 for fish embryos and lgP for 30 different chemicals. The dependences were obtained by constructing a trend line between experimental points and calculation of Pearson’s R correlation coefficient as a measure of regression significance. These dependences can show the influence of substance lipophilicity on its toxicity for aquatic organisms comparing to mammals.
作者简介
K. Zolotarev
V. N. Orekhovich Research Institute of Biomedical Chemistry
编辑信件的主要联系方式.
Email: fireaxe@mail.ru
俄罗斯联邦, Moscow
N. Belyaeva
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: fireaxe@mail.ru
俄罗斯联邦, Moscow
A. Mikhailov
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: fireaxe@mail.ru
俄罗斯联邦, Moscow
M. Mikhailova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: fireaxe@mail.ru
俄罗斯联邦, Moscow