Involvement of Glucagon-Like Peptide-1 in the Regulation of Selective Excretion of Sodium or Chloride Ions by the Kidneys
- Authors: Marina A.S.1, Kutina A.V.1, Shakhmatoba E.I.1, Natochin Y.V.1
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Affiliations:
- I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
- Issue: Vol 162, No 4 (2017)
- Pages: 436-440
- Section: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/238282
- DOI: https://doi.org/10.1007/s10517-017-3634-0
- ID: 238282
Cite item
Abstract
An increase of total glucagon-like peptide-1 (GLP-1) concentration in the plasma in rats was revealed 5 min after oral, but not intraperitoneal administration of NaCl or Trizma HCl solutions. The increase in GLP-1 level was similar to that after oral glucose administration. After intraperitoneal administration of 2.5% NaCl, GLP-1 mimetic exenatide accelerated natriuresis and urinary chloride excretion. Under conditions of normonatriemia and hyperchloremia induced by injection of 6.7% Trizma HCl, exenatide stimulated chloride excretion and reabsorption of sodium ions in the kidneys. These findings suggest that GLP-1 participates in selective regulation of the balance of sodium and chloride ions.
About the authors
A. S. Marina
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Author for correspondence.
Email: annamarina@bk.ru
Russian Federation, St. Petersburg
A. V. Kutina
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: annamarina@bk.ru
Russian Federation, St. Petersburg
E. I. Shakhmatoba
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: annamarina@bk.ru
Russian Federation, St. Petersburg
Yu. V. Natochin
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: annamarina@bk.ru
Russian Federation, St. Petersburg