Involvement of Glucagon-Like Peptide-1 in the Regulation of Selective Excretion of Sodium or Chloride Ions by the Kidneys
- 作者: Marina A.1, Kutina A.1, Shakhmatoba E.1, Natochin Y.1
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隶属关系:
- I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
- 期: 卷 162, 编号 4 (2017)
- 页面: 436-440
- 栏目: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/238282
- DOI: https://doi.org/10.1007/s10517-017-3634-0
- ID: 238282
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详细
An increase of total glucagon-like peptide-1 (GLP-1) concentration in the plasma in rats was revealed 5 min after oral, but not intraperitoneal administration of NaCl or Trizma HCl solutions. The increase in GLP-1 level was similar to that after oral glucose administration. After intraperitoneal administration of 2.5% NaCl, GLP-1 mimetic exenatide accelerated natriuresis and urinary chloride excretion. Under conditions of normonatriemia and hyperchloremia induced by injection of 6.7% Trizma HCl, exenatide stimulated chloride excretion and reabsorption of sodium ions in the kidneys. These findings suggest that GLP-1 participates in selective regulation of the balance of sodium and chloride ions.
作者简介
A. Marina
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: annamarina@bk.ru
俄罗斯联邦, St. Petersburg
A. Kutina
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: annamarina@bk.ru
俄罗斯联邦, St. Petersburg
E. Shakhmatoba
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: annamarina@bk.ru
俄罗斯联邦, St. Petersburg
Yu. Natochin
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: annamarina@bk.ru
俄罗斯联邦, St. Petersburg