Email this article Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer
- Authors: Osip’yants A.I.1,2, Knyazev E.N.1,2, Galatenko A.V.1, Nyushko K.M.2, Galatenko V.V.1, Shkurnikov M.Y.2, Alekseev B.Y.2
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Affiliations:
- BioClinicum Research and Development Centre
- P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation
- Issue: Vol 162, No 3 (2017)
- Pages: 379-382
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/238230
- DOI: https://doi.org/10.1007/s10517-017-3620-6
- ID: 238230
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Abstract
We performed diagnostic classification of plasma specimens from patients with non-metastatic and metastatic prostate cancer based on pairs of miRNA that have no individual diagnostic significance. Of 230 miRNA detected in plasma specimens, 3 pairs were diagnostically significant. The miRNA pair hsa-miR-19b-3p and hsa-miR-297 demonstrated highest sensitivity and specificity. Among common target genes of these miRNA, CFL2 gene associated with cell mobility was detected.
About the authors
A. I. Osip’yants
BioClinicum Research and Development Centre; P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation
Email: mshkurnikov@gmail.com
Russian Federation, Moscow; Moscow
E. N. Knyazev
BioClinicum Research and Development Centre; P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation
Email: mshkurnikov@gmail.com
Russian Federation, Moscow; Moscow
A. V. Galatenko
BioClinicum Research and Development Centre
Email: mshkurnikov@gmail.com
Russian Federation, Moscow
K. M. Nyushko
P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation
Email: mshkurnikov@gmail.com
Russian Federation, Moscow
V. V. Galatenko
BioClinicum Research and Development Centre
Email: mshkurnikov@gmail.com
Russian Federation, Moscow
M. Yu. Shkurnikov
P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation
Author for correspondence.
Email: mshkurnikov@gmail.com
Russian Federation, Moscow
B. Ya. Alekseev
P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation
Email: mshkurnikov@gmail.com
Russian Federation, Moscow
