Enviar artigo por via de e-mail Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer
- Autores: Osip’yants A.1,2, Knyazev E.1,2, Galatenko A.1, Nyushko K.2, Galatenko V.1, Shkurnikov M.2, Alekseev B.2
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Afiliações:
- BioClinicum Research and Development Centre
- P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation
- Edição: Volume 162, Nº 3 (2017)
- Páginas: 379-382
- Seção: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/238230
- DOI: https://doi.org/10.1007/s10517-017-3620-6
- ID: 238230
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Resumo
We performed diagnostic classification of plasma specimens from patients with non-metastatic and metastatic prostate cancer based on pairs of miRNA that have no individual diagnostic significance. Of 230 miRNA detected in plasma specimens, 3 pairs were diagnostically significant. The miRNA pair hsa-miR-19b-3p and hsa-miR-297 demonstrated highest sensitivity and specificity. Among common target genes of these miRNA, CFL2 gene associated with cell mobility was detected.
Sobre autores
A. Osip’yants
BioClinicum Research and Development Centre; P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation
Email: mshkurnikov@gmail.com
Rússia, Moscow; Moscow
E. Knyazev
BioClinicum Research and Development Centre; P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation
Email: mshkurnikov@gmail.com
Rússia, Moscow; Moscow
A. Galatenko
BioClinicum Research and Development Centre
Email: mshkurnikov@gmail.com
Rússia, Moscow
K. Nyushko
P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation
Email: mshkurnikov@gmail.com
Rússia, Moscow
V. Galatenko
BioClinicum Research and Development Centre
Email: mshkurnikov@gmail.com
Rússia, Moscow
M. Shkurnikov
P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: mshkurnikov@gmail.com
Rússia, Moscow
B. Alekseev
P.A. Herzen Moscow Oncology Research Institute, Ministry of Health of the Russian Federation
Email: mshkurnikov@gmail.com
Rússia, Moscow
