Email this article Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride
- Authors: Vyshtakalyuk A.B.1, Nazarov N.G.1,2, Zobov V.V.1,2, Abdulkhakov S.R.2, Minnekhanova O.A.1, Semenov V.E.1, Galyametdinova I.V.1, Cherepnev G.V.1,3, Reznik V.S.1
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Affiliations:
- A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
- Kazan (Volga Region) Federal University
- Medical Unit of Kazan (Volga Region) Federal University
- Issue: Vol 162, No 3 (2017)
- Pages: 340-342
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238182
- DOI: https://doi.org/10.1007/s10517-017-3610-8
- ID: 238182
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Abstract
Hepatoprotective properties of a new pyrimidine derivative — L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, synthesized on the basis Xymedon, were assessed in white rats exposed to CCl4. The compound under study administered prior to exposure to CCl4 reduced the deviation of biochemical parameters from reference values and severity of structural and morphological changes in liver, when compared to the control. Hepatoprotective properties of the studied compound were more pronounced than those of Xymedon.
About the authors
A. B. Vyshtakalyuk
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
Author for correspondence.
Email: alex.vysh@mail.ru
Russian Federation, Kazan
N. G. Nazarov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences; Kazan (Volga Region) Federal University
Email: alex.vysh@mail.ru
Russian Federation, Kazan; Kazan
V. V. Zobov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences; Kazan (Volga Region) Federal University
Email: alex.vysh@mail.ru
Russian Federation, Kazan; Kazan
S. R. Abdulkhakov
Kazan (Volga Region) Federal University
Email: alex.vysh@mail.ru
Russian Federation, Kazan
O. A. Minnekhanova
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
Email: alex.vysh@mail.ru
Russian Federation, Kazan
V. E. Semenov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
Email: alex.vysh@mail.ru
Russian Federation, Kazan
I. V. Galyametdinova
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
Email: alex.vysh@mail.ru
Russian Federation, Kazan
G. V. Cherepnev
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences; Medical Unit of Kazan (Volga Region) Federal University
Email: alex.vysh@mail.ru
Russian Federation, Kazan; Kazan
V. S. Reznik
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
Email: alex.vysh@mail.ru
Russian Federation, Kazan
