Evaluation of the Hepatoprotective Effect of L-Ascorbate 1-(2-Hydroxyethyl)-4,6-Dimethyl-1,2-Dihydropyrimidine-2-One Upon Exposure to Carbon Tetrachloride
- 作者: Vyshtakalyuk A.1, Nazarov N.1,2, Zobov V.1,2, Abdulkhakov S.2, Minnekhanova O.1, Semenov V.1, Galyametdinova I.1, Cherepnev G.1,3, Reznik V.1
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隶属关系:
- A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
- Kazan (Volga Region) Federal University
- Medical Unit of Kazan (Volga Region) Federal University
- 期: 卷 162, 编号 3 (2017)
- 页面: 340-342
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238182
- DOI: https://doi.org/10.1007/s10517-017-3610-8
- ID: 238182
如何引用文章
详细
Hepatoprotective properties of a new pyrimidine derivative — L-ascorbate 1-(2-hydroxyethyl)-4,6-dimethyl-1,2-dihydropyrimidine-2-one, synthesized on the basis Xymedon, were assessed in white rats exposed to CCl4. The compound under study administered prior to exposure to CCl4 reduced the deviation of biochemical parameters from reference values and severity of structural and morphological changes in liver, when compared to the control. Hepatoprotective properties of the studied compound were more pronounced than those of Xymedon.
作者简介
A. Vyshtakalyuk
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: alex.vysh@mail.ru
俄罗斯联邦, Kazan
N. Nazarov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences; Kazan (Volga Region) Federal University
Email: alex.vysh@mail.ru
俄罗斯联邦, Kazan; Kazan
V. Zobov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences; Kazan (Volga Region) Federal University
Email: alex.vysh@mail.ru
俄罗斯联邦, Kazan; Kazan
S. Abdulkhakov
Kazan (Volga Region) Federal University
Email: alex.vysh@mail.ru
俄罗斯联邦, Kazan
O. Minnekhanova
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
Email: alex.vysh@mail.ru
俄罗斯联邦, Kazan
V. Semenov
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
Email: alex.vysh@mail.ru
俄罗斯联邦, Kazan
I. Galyametdinova
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
Email: alex.vysh@mail.ru
俄罗斯联邦, Kazan
G. Cherepnev
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences; Medical Unit of Kazan (Volga Region) Federal University
Email: alex.vysh@mail.ru
俄罗斯联邦, Kazan; Kazan
V. Reznik
A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center of the Russian Academy of Sciences
Email: alex.vysh@mail.ru
俄罗斯联邦, Kazan
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