Email this article Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus
- Authors: Michurina S.V.1,2, Ishchenko I.Y.1,2, Arkhipov S.A.1,2, Klimontov V.V.1,2, Rachkovskaya L.N.1,2, Konenkov V.I.1,2, Zavyalov E.L.1,2
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Affiliations:
- Research Institute of Clinical and Experimental Lymphology
- Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 162, No 2 (2016)
- Pages: 269-272
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238106
- DOI: https://doi.org/10.1007/s10517-016-3592-y
- ID: 238106
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Abstract
The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gavage from week 8 to week 16 of life. The animals receiving the complex exhibited enhanced, in comparison with the placebo group, immunohistochemical LYVE-1+ staining of endothelial cells in sinusoids. Enhanced expression of LYVE-1 was associated with less pronounced dilatation of interlobular arteries, veins, and lymphatic vessels. Thee findings suggest a protective effect of the complex towards structural changes in the liver of mice with obesity and type 2 diabetes.
About the authors
S. V. Michurina
Research Institute of Clinical and Experimental Lymphology; Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: s.michurina@ngs.ru
Russian Federation, Novosibirsk; Novosibirsk
I. Yu. Ishchenko
Research Institute of Clinical and Experimental Lymphology; Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Russian Federation, Novosibirsk; Novosibirsk
S. A. Arkhipov
Research Institute of Clinical and Experimental Lymphology; Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Russian Federation, Novosibirsk; Novosibirsk
V. V. Klimontov
Research Institute of Clinical and Experimental Lymphology; Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Russian Federation, Novosibirsk; Novosibirsk
L. N. Rachkovskaya
Research Institute of Clinical and Experimental Lymphology; Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Russian Federation, Novosibirsk; Novosibirsk
V. I. Konenkov
Research Institute of Clinical and Experimental Lymphology; Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Russian Federation, Novosibirsk; Novosibirsk
E. L. Zavyalov
Research Institute of Clinical and Experimental Lymphology; Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Russian Federation, Novosibirsk; Novosibirsk
