Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus
- Autores: Michurina S.1,2, Ishchenko I.1,2, Arkhipov S.1,2, Klimontov V.1,2, Rachkovskaya L.1,2, Konenkov V.1,2, Zavyalov E.1,2
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Afiliações:
- Research Institute of Clinical and Experimental Lymphology
- Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Edição: Volume 162, Nº 2 (2016)
- Páginas: 269-272
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238106
- DOI: https://doi.org/10.1007/s10517-016-3592-y
- ID: 238106
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Resumo
The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gavage from week 8 to week 16 of life. The animals receiving the complex exhibited enhanced, in comparison with the placebo group, immunohistochemical LYVE-1+ staining of endothelial cells in sinusoids. Enhanced expression of LYVE-1 was associated with less pronounced dilatation of interlobular arteries, veins, and lymphatic vessels. Thee findings suggest a protective effect of the complex towards structural changes in the liver of mice with obesity and type 2 diabetes.
Sobre autores
S. Michurina
Research Institute of Clinical and Experimental Lymphology; Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: s.michurina@ngs.ru
Rússia, Novosibirsk; Novosibirsk
I. Ishchenko
Research Institute of Clinical and Experimental Lymphology; Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Rússia, Novosibirsk; Novosibirsk
S. Arkhipov
Research Institute of Clinical and Experimental Lymphology; Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Rússia, Novosibirsk; Novosibirsk
V. Klimontov
Research Institute of Clinical and Experimental Lymphology; Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Rússia, Novosibirsk; Novosibirsk
L. Rachkovskaya
Research Institute of Clinical and Experimental Lymphology; Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Rússia, Novosibirsk; Novosibirsk
V. Konenkov
Research Institute of Clinical and Experimental Lymphology; Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Rússia, Novosibirsk; Novosibirsk
E. Zavyalov
Research Institute of Clinical and Experimental Lymphology; Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Rússia, Novosibirsk; Novosibirsk
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