Email this article Proinflammatory Cytokines as Regulators of Vaginal Microbiota
- Authors: Kremleva E.A.1,2, Sgibnev A.V.1
-
Affiliations:
- Institute of Cellular and Intracellular Symbiosis, Ural Division of the Russian Academy of Sciences
- Orenburg State Medical University, Ministry of Healthcare of the Russian Federation
- Issue: Vol 162, No 1 (2016)
- Pages: 75-78
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237918
- DOI: https://doi.org/10.1007/s10517-016-3549-1
- ID: 237918
Cite item
Open Access
Access granted
Subscription Access
Abstract
It was shown that IL-1β, IL-8, and IL-6 in concentrations similar to those in the vagina of healthy women stimulated the growth of normal microflora (Lactobacillus spp.) and suppressed the growth and biofilm production by S. aureus and E. coli. On the contrary, these cytokines in higher concentrations typical of vaginal dysbiosis suppressed normal microflora and stimulated the growth of opportunistic microorganisms. TGF-β1 in both doses produced a stimulating effects on study vaginal microsymbionts. It is hypothesized that pro-inflammatory cytokines serve as the molecules of interspecies communication coordinating the interactions of all components of the vaginal symbiotic system.
About the authors
E. A. Kremleva
Institute of Cellular and Intracellular Symbiosis, Ural Division of the Russian Academy of Sciences; Orenburg State Medical University, Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: kremlena1@mail.ru
Russian Federation, Orenburg; Orenburg
A. V. Sgibnev
Institute of Cellular and Intracellular Symbiosis, Ural Division of the Russian Academy of Sciences
Email: kremlena1@mail.ru
Russian Federation, Orenburg
