Proinflammatory Cytokines as Regulators of Vaginal Microbiota
- 作者: Kremleva E.1,2, Sgibnev A.1
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隶属关系:
- Institute of Cellular and Intracellular Symbiosis, Ural Division of the Russian Academy of Sciences
- Orenburg State Medical University, Ministry of Healthcare of the Russian Federation
- 期: 卷 162, 编号 1 (2016)
- 页面: 75-78
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237918
- DOI: https://doi.org/10.1007/s10517-016-3549-1
- ID: 237918
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详细
It was shown that IL-1β, IL-8, and IL-6 in concentrations similar to those in the vagina of healthy women stimulated the growth of normal microflora (Lactobacillus spp.) and suppressed the growth and biofilm production by S. aureus and E. coli. On the contrary, these cytokines in higher concentrations typical of vaginal dysbiosis suppressed normal microflora and stimulated the growth of opportunistic microorganisms. TGF-β1 in both doses produced a stimulating effects on study vaginal microsymbionts. It is hypothesized that pro-inflammatory cytokines serve as the molecules of interspecies communication coordinating the interactions of all components of the vaginal symbiotic system.
作者简介
E. Kremleva
Institute of Cellular and Intracellular Symbiosis, Ural Division of the Russian Academy of Sciences; Orenburg State Medical University, Ministry of Healthcare of the Russian Federation
编辑信件的主要联系方式.
Email: kremlena1@mail.ru
俄罗斯联邦, Orenburg; Orenburg
A. Sgibnev
Institute of Cellular and Intracellular Symbiosis, Ural Division of the Russian Academy of Sciences
Email: kremlena1@mail.ru
俄罗斯联邦, Orenburg