Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss

V. V. Zhdanov; L. A. Miroshnichenko; E. V. Udut; G. N. Zyuz’kov; T. Yu. Khrichkova; E. V. Simanina; E. Yu. Sherstoboev; L. A. Stavrova; V. I. Agafonov; A. V. Chaikovskii; M. Yu. Minakova; A. M. Dygai

doi:10.1007/s10517-016-3543-7

Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss

Authors: Zhdanov V.V.¹, Miroshnichenko L.A.¹, Udut E.V.¹, Zyuz’kov G.N.¹, Khrichkova T.Y.¹, Simanina E.V.¹, Sherstoboev E.Y.¹, Stavrova L.A.¹, Agafonov V.I.¹, Chaikovskii A.V.¹, Minakova M.Y.¹, Dygai A.M.¹
Affiliations:
1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Issue: Vol 162, No 1 (2016)
Pages: 51-55
Section: Pharmacology and Toxicology
URL: https://journals.rcsi.science/0007-4888/article/view/237898
DOI: https://doi.org/10.1007/s10517-016-3543-7
ID: 237898

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Abstract

The leading role in the regulation of erythropoietic activity of adherent bone marrow cells under conditions of post-hemorrhagic anemia is played by classical MAP kinase pathway (ERK pathway). Erythropoietin is not the decisive factor in the formation of erythropoietic activity of adherent cells. PI3K, MAPK/ERK 1/2, and p38-signaling proteins are not the main regulators of local production of erythropoietin after 30% loss of circulating blood volume.