Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss
- 作者: Zhdanov V.1, Miroshnichenko L.1, Udut E.1, Zyuz’kov G.1, Khrichkova T.1, Simanina E.1, Sherstoboev E.1, Stavrova L.1, Agafonov V.1, Chaikovskii A.1, Minakova M.1, Dygai A.1
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隶属关系:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- 期: 卷 162, 编号 1 (2016)
- 页面: 51-55
- 栏目: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/237898
- DOI: https://doi.org/10.1007/s10517-016-3543-7
- ID: 237898
如何引用文章
详细
The leading role in the regulation of erythropoietic activity of adherent bone marrow cells under conditions of post-hemorrhagic anemia is played by classical MAP kinase pathway (ERK pathway). Erythropoietin is not the decisive factor in the formation of erythropoietic activity of adherent cells. PI3K, MAPK/ERK 1/2, and p38-signaling proteins are not the main regulators of local production of erythropoietin after 30% loss of circulating blood volume.
作者简介
V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: laarmi@yandex.ru
俄罗斯联邦, Tomsk
L. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
编辑信件的主要联系方式.
Email: laarmi@yandex.ru
俄罗斯联邦, Tomsk
E. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: laarmi@yandex.ru
俄罗斯联邦, Tomsk
G. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: laarmi@yandex.ru
俄罗斯联邦, Tomsk
T. Khrichkova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: laarmi@yandex.ru
俄罗斯联邦, Tomsk
E. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: laarmi@yandex.ru
俄罗斯联邦, Tomsk
E. Sherstoboev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: laarmi@yandex.ru
俄罗斯联邦, Tomsk
L. Stavrova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: laarmi@yandex.ru
俄罗斯联邦, Tomsk
V. Agafonov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: laarmi@yandex.ru
俄罗斯联邦, Tomsk
A. Chaikovskii
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: laarmi@yandex.ru
俄罗斯联邦, Tomsk
M. Minakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: laarmi@yandex.ru
俄罗斯联邦, Tomsk
A. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: laarmi@yandex.ru
俄罗斯联邦, Tomsk
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