Email this article Peculiar Aspects in Influence of α1-Adrenoceptor Stimulation on Isolated Rat Heart
- Authors: Zefirov T.L.1, Khabibrakhmanov I.I.1, Ziyatdinova N.I.1, Zefirov A.L.2
-
Affiliations:
- Department of Human Health Protection, Kazan (Volga Region) Federal University
- Department of Normal Physiology, Kazan Federal Medical University
- Issue: Vol 162, No 1 (2016)
- Pages: 4-6
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237858
- DOI: https://doi.org/10.1007/s10517-016-3530-z
- ID: 237858
Cite item
Open Access
Access granted
Subscription Access
Abstract
The study examined the effect of α1-adrenoceptor stimulation with methoxamine on chronotropic function of isolated heart perfused ex vivo according to Langendorff and cardiac chronotropy in vivo. Stimulation of α1-adrenoceptors in isolated heart induced gradually developing bradycardia, which progressed during several minutes. Similar stimulation in vivo produced a short-term bradycardia probably terminated by the compensatory influences in the whole organism. Comparison of the data obtained in both experimental paradigms during α1-adrenoceptor stimulation revealed unidirectional changes in cardiac chronotropy characterized with time-related peculiarities.
About the authors
T. L. Zefirov
Department of Human Health Protection, Kazan (Volga Region) Federal University
Author for correspondence.
Email: zefirovtl@mail.ru
Russian Federation, Kazan, the Republic of Tatarstan
I. I. Khabibrakhmanov
Department of Human Health Protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, the Republic of Tatarstan
N. I. Ziyatdinova
Department of Human Health Protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, the Republic of Tatarstan
A. L. Zefirov
Department of Normal Physiology, Kazan Federal Medical University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, the Republic of Tatarstan
