Peculiar Aspects in Influence of α1-Adrenoceptor Stimulation on Isolated Rat Heart
- Авторлар: Zefirov T.1, Khabibrakhmanov I.1, Ziyatdinova N.1, Zefirov A.2
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Мекемелер:
- Department of Human Health Protection, Kazan (Volga Region) Federal University
- Department of Normal Physiology, Kazan Federal Medical University
- Шығарылым: Том 162, № 1 (2016)
- Беттер: 4-6
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237858
- DOI: https://doi.org/10.1007/s10517-016-3530-z
- ID: 237858
Дәйексөз келтіру
Аннотация
The study examined the effect of α1-adrenoceptor stimulation with methoxamine on chronotropic function of isolated heart perfused ex vivo according to Langendorff and cardiac chronotropy in vivo. Stimulation of α1-adrenoceptors in isolated heart induced gradually developing bradycardia, which progressed during several minutes. Similar stimulation in vivo produced a short-term bradycardia probably terminated by the compensatory influences in the whole organism. Comparison of the data obtained in both experimental paradigms during α1-adrenoceptor stimulation revealed unidirectional changes in cardiac chronotropy characterized with time-related peculiarities.
Авторлар туралы
T. Zefirov
Department of Human Health Protection, Kazan (Volga Region) Federal University
Хат алмасуға жауапты Автор.
Email: zefirovtl@mail.ru
Ресей, Kazan, the Republic of Tatarstan
I. Khabibrakhmanov
Department of Human Health Protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Ресей, Kazan, the Republic of Tatarstan
N. Ziyatdinova
Department of Human Health Protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Ресей, Kazan, the Republic of Tatarstan
A. Zefirov
Department of Normal Physiology, Kazan Federal Medical University
Email: zefirovtl@mail.ru
Ресей, Kazan, the Republic of Tatarstan
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