Email this article Effects of Melatonin on Differentiation Potential of Ito Cells in Mice with Induced Fibrosis of the Liver
- Authors: Nalobin D.S.1, Suprunenko E.A.1, Golichenkov V.A.1
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Affiliations:
- M. V. Lomonosov Moscow State University
- Issue: Vol 161, No 6 (2016)
- Pages: 845-849
- Section: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/237843
- DOI: https://doi.org/10.1007/s10517-016-3526-8
- ID: 237843
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Abstract
We studied the effects of melatonin on differentiation potential of Ito cells during atypical regeneration of mouse liver under conditions of CCl4-induced fibrosis. The dynamics of fibrosis was traced at the histological level and the effects of melatonin on the differentiation potential of mouse Ito cells were evaluated. Melatonin alleviated fibrotic changes in the liver tissue and reduced differentiation of Ito cells into myofibroblasts under conditions of atypical regeneration of the liver in induced fibrosis. The hepatoprotective role of melatonin was shown.
About the authors
D. S. Nalobin
M. V. Lomonosov Moscow State University
Author for correspondence.
Email: denis.nalobin@gmail.com
Russian Federation, Moscow
E. A. Suprunenko
M. V. Lomonosov Moscow State University
Email: denis.nalobin@gmail.com
Russian Federation, Moscow
V. A. Golichenkov
M. V. Lomonosov Moscow State University
Email: denis.nalobin@gmail.com
Russian Federation, Moscow
