Email this article Pulsed Dendritic Cells for the Therapy of Experimental Glioma
- Authors: Chekhonin I.V.1, Gurina O.I.1, Cherepanov S.A.2, Abakumov M.A.2, Ionova K.P.1, Zhigarev D.K.1, Makarov A.V.1, Chekhonin V.P.1,2
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Affiliations:
- V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation
- Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 161, No 6 (2016)
- Pages: 792-796
- Section: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/237786
- DOI: https://doi.org/10.1007/s10517-016-3512-1
- ID: 237786
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Abstract
We obtained the morphologically, cytofluorometrically, and functionally mature dendritic cells from rats that were pulsed with antigens of the C6 glioma tissue extract. The concentrations of angiogenesis antigens (VEGF, VEGFR-1, and VEGFR-2) and periglioma zone proteins (GFAP, connexin 43, and BSAT1) in the pulsing extract were measured by ELISA. Our results drove us to a conclusion that despite mature phenotype of pulsed dendritic cell, the antigenic composition of glioma tissue extracts should be modified.
About the authors
I. V. Chekhonin
V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: ivan-chekhonin@yandex.ru
Russian Federation, Moscow
O. I. Gurina
V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: ivan-chekhonin@yandex.ru
Russian Federation, Moscow
S. A. Cherepanov
Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: ivan-chekhonin@yandex.ru
Russian Federation, Moscow
M. A. Abakumov
Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: ivan-chekhonin@yandex.ru
Russian Federation, Moscow
K. P. Ionova
V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: ivan-chekhonin@yandex.ru
Russian Federation, Moscow
D. K. Zhigarev
V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: ivan-chekhonin@yandex.ru
Russian Federation, Moscow
A. V. Makarov
V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation
Email: ivan-chekhonin@yandex.ru
Russian Federation, Moscow
V. P. Chekhonin
V. P. Serbsky Federal Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation; Department of Medical Nanobiotechnologies, Medical Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: ivan-chekhonin@yandex.ru
Russian Federation, Moscow; Moscow
