Email this article Spatial Memory in the Progeny of Rats Subjected to Different Types of Experimental Preeclampsia
- Authors: Perfilova V.N.1, Zhakupova G.A.1, Lashchenova L.I.1, Lebedeva S.A.1,2, Tyurenkov I.N.1
-
Affiliations:
- Volgograd State Medical University
- Research Institute for Pharmacology of Volgograd State Medical University
- Issue: Vol 161, No 5 (2016)
- Pages: 643-646
- Section: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/237637
- DOI: https://doi.org/10.1007/s10517-016-3475-2
- ID: 237637
Cite item
Open Access
Access granted
Subscription Access
Abstract
Spatial memory was studied in 2-month-old offspring of rats subjected to different types of experimental preeclampsia (replacement of drinking water with 1.8% NaCl from day 1 to 21 of gestation or intraperitoneal administration of non-selective NO-synthase inhibitor L-NAME to pregnant rats in a daily dose of 25 mg/kg for 7 days on gestation days 14-20). Spatial memory was evaluated in an elevated 8-arm radial maze. Both types of experimental preeclampsia impaired spatial (long-term and short-term) memory and can be used in the development of drugs correcting negative effects of this pregnancy complication on memory.
About the authors
V. N. Perfilova
Volgograd State Medical University
Email: g.a.zhakupova@yandex.ru
Russian Federation, Volgograd
G. A. Zhakupova
Volgograd State Medical University
Author for correspondence.
Email: g.a.zhakupova@yandex.ru
Russian Federation, Volgograd
L. I. Lashchenova
Volgograd State Medical University
Email: g.a.zhakupova@yandex.ru
Russian Federation, Volgograd
S. A. Lebedeva
Volgograd State Medical University; Research Institute for Pharmacology of Volgograd State Medical University
Email: g.a.zhakupova@yandex.ru
Russian Federation, Volgograd; Volgograd
I. N. Tyurenkov
Volgograd State Medical University
Email: g.a.zhakupova@yandex.ru
Russian Federation, Volgograd
Supplementary files
