Spatial Memory in the Progeny of Rats Subjected to Different Types of Experimental Preeclampsia
- Autores: Perfilova V.1, Zhakupova G.1, Lashchenova L.1, Lebedeva S.1,2, Tyurenkov I.1
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Afiliações:
- Volgograd State Medical University
- Research Institute for Pharmacology of Volgograd State Medical University
- Edição: Volume 161, Nº 5 (2016)
- Páginas: 643-646
- Seção: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/237637
- DOI: https://doi.org/10.1007/s10517-016-3475-2
- ID: 237637
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Resumo
Spatial memory was studied in 2-month-old offspring of rats subjected to different types of experimental preeclampsia (replacement of drinking water with 1.8% NaCl from day 1 to 21 of gestation or intraperitoneal administration of non-selective NO-synthase inhibitor L-NAME to pregnant rats in a daily dose of 25 mg/kg for 7 days on gestation days 14-20). Spatial memory was evaluated in an elevated 8-arm radial maze. Both types of experimental preeclampsia impaired spatial (long-term and short-term) memory and can be used in the development of drugs correcting negative effects of this pregnancy complication on memory.
Sobre autores
V. Perfilova
Volgograd State Medical University
Email: g.a.zhakupova@yandex.ru
Rússia, Volgograd
G. Zhakupova
Volgograd State Medical University
Autor responsável pela correspondência
Email: g.a.zhakupova@yandex.ru
Rússia, Volgograd
L. Lashchenova
Volgograd State Medical University
Email: g.a.zhakupova@yandex.ru
Rússia, Volgograd
S. Lebedeva
Volgograd State Medical University; Research Institute for Pharmacology of Volgograd State Medical University
Email: g.a.zhakupova@yandex.ru
Rússia, Volgograd; Volgograd
I. Tyurenkov
Volgograd State Medical University
Email: g.a.zhakupova@yandex.ru
Rússia, Volgograd