Experimental Evaluation of Biodegradable Film Compositions Based on Gelatin with Colchicine

L. A. Bokeriya; O. L. Bokeriya; V. S. Sivtsev; S. P. Novikova; R. R. Salokhedinova; L. N. Nikolashina; N. N. Samsonova; A. Yu. Gorodkov; R. A. Serov

doi:10.1007/s10517-016-3428-9

Experimental Evaluation of Biodegradable Film Compositions Based on Gelatin with Colchicine

Authors: Bokeriya L.A.¹, Bokeriya O.L.¹, Sivtsev V.S.¹, Novikova S.P.¹, Salokhedinova R.R.¹, Nikolashina L.N.¹, Samsonova N.N.¹, Gorodkov A.Y.¹, Serov R.A.¹
Affiliations:
1. A.N. Bakoulev Scientific Center for Cardiovascular Surgery
Issue: Vol 161, No 3 (2016)
Pages: 414-418
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/237472
DOI: https://doi.org/10.1007/s10517-016-3428-9
ID: 237472

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Abstract

Biodegradable film compositions based on natural biopolymer gelatin with immobilized colchicine were prepared and their efficiency in prevention of the adhesion process in the pericardium was evaluated on rabbit model of postoperative pericarditis. The use of gelatin-based biodegradable film compositions significantly reduced the intensity of adhesion formation in the pericardial cavity, while immobilization of anti-inflammatory drug colchicine amplified their anti-adhesion activity.