Experimental Evaluation of Biodegradable Film Compositions Based on Gelatin with Colchicine
- Authors: Bokeriya L.A.1, Bokeriya O.L.1, Sivtsev V.S.1, Novikova S.P.1, Salokhedinova R.R.1, Nikolashina L.N.1, Samsonova N.N.1, Gorodkov A.Y.1, Serov R.A.1
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Affiliations:
- A.N. Bakoulev Scientific Center for Cardiovascular Surgery
- Issue: Vol 161, No 3 (2016)
- Pages: 414-418
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237472
- DOI: https://doi.org/10.1007/s10517-016-3428-9
- ID: 237472
Cite item
Abstract
Biodegradable film compositions based on natural biopolymer gelatin with immobilized colchicine were prepared and their efficiency in prevention of the adhesion process in the pericardium was evaluated on rabbit model of postoperative pericarditis. The use of gelatin-based biodegradable film compositions significantly reduced the intensity of adhesion formation in the pericardial cavity, while immobilization of anti-inflammatory drug colchicine amplified their anti-adhesion activity.
About the authors
L. A. Bokeriya
A.N. Bakoulev Scientific Center for Cardiovascular Surgery
Email: spnovikova@bakulev.ru
Russian Federation, Moscow
O. L. Bokeriya
A.N. Bakoulev Scientific Center for Cardiovascular Surgery
Email: spnovikova@bakulev.ru
Russian Federation, Moscow
V. S. Sivtsev
A.N. Bakoulev Scientific Center for Cardiovascular Surgery
Email: spnovikova@bakulev.ru
Russian Federation, Moscow
S. P. Novikova
A.N. Bakoulev Scientific Center for Cardiovascular Surgery
Author for correspondence.
Email: spnovikova@bakulev.ru
Russian Federation, Moscow
R. R. Salokhedinova
A.N. Bakoulev Scientific Center for Cardiovascular Surgery
Email: spnovikova@bakulev.ru
Russian Federation, Moscow
L. N. Nikolashina
A.N. Bakoulev Scientific Center for Cardiovascular Surgery
Email: spnovikova@bakulev.ru
Russian Federation, Moscow
N. N. Samsonova
A.N. Bakoulev Scientific Center for Cardiovascular Surgery
Email: spnovikova@bakulev.ru
Russian Federation, Moscow
A. Yu. Gorodkov
A.N. Bakoulev Scientific Center for Cardiovascular Surgery
Email: spnovikova@bakulev.ru
Russian Federation, Moscow
R. A. Serov
A.N. Bakoulev Scientific Center for Cardiovascular Surgery
Email: spnovikova@bakulev.ru
Russian Federation, Moscow