Oxidative Stress and Catalase Gene

O. A. Ershova; T. A. Bairova; S. I. Kolesnikov; O. V. Kalyuzhnaya; M. A. Darenskaya; L. I. Kolesnikova

doi:10.1007/s10517-016-3424-0

Oxidative Stress and Catalase Gene

Authors: Ershova O.A.¹, Bairova T.A.¹, Kolesnikov S.I.¹, Kalyuzhnaya O.V.¹, Darenskaya M.A.¹, Kolesnikova L.I.¹
Affiliations:
1. Research Center of Family Health and Human Reproduction Problems
Issue: Vol 161, No 3 (2016)
Pages: 400-403
Section: Genetics
URL: https://journals.rcsi.science/0007-4888/article/view/237459
DOI: https://doi.org/10.1007/s10517-016-3424-0
ID: 237459

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Abstract
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Abstract

We studied the frequency of alleles and genotypes of CAT gene -262C>T polymorphism (rs1001179) in Russian and Buryat adolescents. The frequency of -262T allele was 28.31% in Russians and 16.84% in Buryats (p<0.01). In both ethnic groups, a correlation between the study polymorphism and concentration of diene conjugates was observed. Carriers of TT-genotype of CAT gene-262C>T polymorphism had lower level of diene conjugates than carriers of CT- and CC-genotypes.