Отправить статью по E-mail Expression of Bax Protein and Morphological Changes in the Myocardium in Experimental Acute Pressure Overload of the Left Ventricle
- Авторы: Blagonravov M.L.1, Korshunova A.Y.1, Azova M.M.2, Bryk A.A.1, Frolov V.A.1
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Учреждения:
- Department of Pathology and Pathological Physiology
- Department of Biology and Common Genetics, Medical Institute, Russian, University of Peoples’ Friendship
- Выпуск: Том 161, № 2 (2016)
- Страницы: 312-315
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237373
- DOI: https://doi.org/10.1007/s10517-016-3403-5
- ID: 237373
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Аннотация
The expression of Bax protein, marker of intracellular pathway of apoptosis initiation, in viable left ventricular cardiomyocytes and morphological changes in the myocardium in acute pressure overload of the left ventricle were studied in experiment on male rabbits. The content of Bax protein in the cardiomyocyte cytoplasm decreased, this indicating that the mitochondrial pathway was not involved in the realization of the apoptotic program. This decrease was associated with manifest destructive changes in the left ventricular myocardium.
Об авторах
M. Blagonravov
Department of Pathology and Pathological Physiology
Email: blagonravovm@mail.ru
Россия, Moscow
A. Korshunova
Department of Pathology and Pathological Physiology
Email: blagonravovm@mail.ru
Россия, Moscow
M. Azova
Department of Biology and Common Genetics, Medical Institute, Russian, University of Peoples’ Friendship
Автор, ответственный за переписку.
Email: blagonravovm@mail.ru
Россия, Moscow
A. Bryk
Department of Pathology and Pathological Physiology
Email: blagonravovm@mail.ru
Россия, Moscow
V. Frolov
Department of Pathology and Pathological Physiology
Email: blagonravovm@mail.ru
Россия, Moscow
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