Plant Polysaccharides Attenuate Fluorouracil Toxicity for the Small Intestinal Epithelium

E. A. Safonova; K. A. Lopatina; A. V. Vychuzhanina; L. A. Ermolaeva; T. G. Razina; E. P. Zueva

doi:10.1007/s10517-016-3402-6

Plant Polysaccharides Attenuate Fluorouracil Toxicity for the Small Intestinal Epithelium

Authors: Safonova E.A.¹, Lopatina K.A.¹, Vychuzhanina A.V.¹, Ermolaeva L.A.¹, Razina T.G.¹, Zueva E.P.¹
Affiliations:
1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Issue: Vol 161, No 2 (2016)
Pages: 308-311
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/237366
DOI: https://doi.org/10.1007/s10517-016-3402-6
ID: 237366

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Abstract

Polysaccharides from Tussilago farfara L., Acorus calamus L., and Echinacea purpurea (L.) Moench attenuated the toxic effect of fl uorouracil on the small intestinal epithelium of mice with Lewis lung carcinoma. Addition of polysaccharides to chemotherapy protocols stimulated reparative regeneration processes in the small intestine damaged by the cytostatic treatment. No stimulating effects of the polysaccharides on tumor growth and metastasizing were revealed.