Email this article New Carbocyclic Amino Acid Derivatives Inhibit Infection Caused by Highly Pathogenic Influenza A Virus Strain (H5N1)
- Authors: Shibnev V.A.1, Garaev T.M.1, Deryabin P.G.1, Finogenova M.P.1, Botikov A.G.1, Mishin D.V.1
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Affiliations:
- D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
- Issue: Vol 161, No 2 (2016)
- Pages: 284-287
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237338
- DOI: https://doi.org/10.1007/s10517-016-3396-0
- ID: 237338
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Abstract
New amino acid derivatives with carbocycles of adamantine and quinaldic acid were synthesized and their in vitro antiviral activity against influenza A/H5N1 virus was evaluated. Experiments on cultured embryonic porcine kidney epithelial cells showed that amino acid derivatives suppressed viral replication. Tret-butyloxycarbonyl-DL-methionylsulfonyl-1-adamantayl ethylamine and benzyloxycarbonyl-L-trypthophanyl-1-adamantayl ethylamine compounds demonstrated high activity in all in vitro experiments. Moreover, some compounds showed virucidal activity against influenza A/H5N1 virus.
About the authors
V. A. Shibnev
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: gtim@fmradio.ru
Russian Federation, Moscow
T. M. Garaev
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: gtim@fmradio.ru
Russian Federation, Moscow
P. G. Deryabin
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: gtim@fmradio.ru
Russian Federation, Moscow
M. P. Finogenova
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: gtim@fmradio.ru
Russian Federation, Moscow
A. G. Botikov
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: gtim@fmradio.ru
Russian Federation, Moscow
D. V. Mishin
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: gtim@fmradio.ru
Russian Federation, Moscow
