New Carbocyclic Amino Acid Derivatives Inhibit Infection Caused by Highly Pathogenic Influenza A Virus Strain (H5N1)
- 作者: Shibnev V.1, Garaev T.1, Deryabin P.1, Finogenova M.1, Botikov A.1, Mishin D.1
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隶属关系:
- D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
- 期: 卷 161, 编号 2 (2016)
- 页面: 284-287
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237338
- DOI: https://doi.org/10.1007/s10517-016-3396-0
- ID: 237338
如何引用文章
详细
New amino acid derivatives with carbocycles of adamantine and quinaldic acid were synthesized and their in vitro antiviral activity against influenza A/H5N1 virus was evaluated. Experiments on cultured embryonic porcine kidney epithelial cells showed that amino acid derivatives suppressed viral replication. Tret-butyloxycarbonyl-DL-methionylsulfonyl-1-adamantayl ethylamine and benzyloxycarbonyl-L-trypthophanyl-1-adamantayl ethylamine compounds demonstrated high activity in all in vitro experiments. Moreover, some compounds showed virucidal activity against influenza A/H5N1 virus.
作者简介
V. Shibnev
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: gtim@fmradio.ru
俄罗斯联邦, Moscow
T. Garaev
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: gtim@fmradio.ru
俄罗斯联邦, Moscow
P. Deryabin
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: gtim@fmradio.ru
俄罗斯联邦, Moscow
M. Finogenova
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: gtim@fmradio.ru
俄罗斯联邦, Moscow
A. Botikov
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: gtim@fmradio.ru
俄罗斯联邦, Moscow
D. Mishin
D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation
Email: gtim@fmradio.ru
俄罗斯联邦, Moscow