Email this article Neuroprotective Effectiveness of Intravenous Ubiquinone in Rat Model of Irreversible Cerebral Ischemia
- Authors: Belousova M.A.1, Tokareva O.G.1, Gorodetskaya E.A.1, Kalenikova E.I.1, Medvedev O.S.1
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Affiliations:
- Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
- Issue: Vol 161, No 2 (2016)
- Pages: 245-247
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/237302
- DOI: https://doi.org/10.1007/s10517-016-3387-1
- ID: 237302
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Abstract
The neuroprotective effect of ubiquinone (coenzyme Q10)was demonstrated on the rats model of ischemic stroke provoked by persistent 24-h occlusion of the middle cerebral artery. Coenzyme Q10 (30 mg/kg) was injected intravenously in 60 min after artery occlusion. Ubiquinone crossed the blood-brain barrier, accumulated in the brain, and produced a neuroprotective effect: it alleviated ischemia-induced neurological deficit and reduced the size of necrotic zone by 49% in comparison with rats receiving physiological saline.
About the authors
M. A. Belousova
Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: margarita.a.belousova@gmail.com
Russian Federation, Moscow
O. G. Tokareva
Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: margarita.a.belousova@gmail.com
Russian Federation, Moscow
E. A. Gorodetskaya
Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: margarita.a.belousova@gmail.com
Russian Federation, Moscow
E. I. Kalenikova
Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: margarita.a.belousova@gmail.com
Russian Federation, Moscow
O. S. Medvedev
Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: margarita.a.belousova@gmail.com
Russian Federation, Moscow
