Neuroprotective Effectiveness of Intravenous Ubiquinone in Rat Model of Irreversible Cerebral Ischemia
- 作者: Belousova M.1, Tokareva O.1, Gorodetskaya E.1, Kalenikova E.1, Medvedev O.1
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隶属关系:
- Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
- 期: 卷 161, 编号 2 (2016)
- 页面: 245-247
- 栏目: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/237302
- DOI: https://doi.org/10.1007/s10517-016-3387-1
- ID: 237302
如何引用文章
详细
The neuroprotective effect of ubiquinone (coenzyme Q10)was demonstrated on the rats model of ischemic stroke provoked by persistent 24-h occlusion of the middle cerebral artery. Coenzyme Q10 (30 mg/kg) was injected intravenously in 60 min after artery occlusion. Ubiquinone crossed the blood-brain barrier, accumulated in the brain, and produced a neuroprotective effect: it alleviated ischemia-induced neurological deficit and reduced the size of necrotic zone by 49% in comparison with rats receiving physiological saline.
作者简介
M. Belousova
Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: margarita.a.belousova@gmail.com
俄罗斯联邦, Moscow
O. Tokareva
Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: margarita.a.belousova@gmail.com
俄罗斯联邦, Moscow
E. Gorodetskaya
Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: margarita.a.belousova@gmail.com
俄罗斯联邦, Moscow
E. Kalenikova
Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: margarita.a.belousova@gmail.com
俄罗斯联邦, Moscow
O. Medvedev
Fundamental Medicine Faculty, M. V. Lomonosov Moscow State University
Email: margarita.a.belousova@gmail.com
俄罗斯联邦, Moscow
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