Email this article Role of Progenitor Cells in Liver Regeneration after Subtotal Resection
- Authors: El’chaninov A.V.1,2,3, Fatkhudinov T.K.1,2,3, Kananykhina E.Y.1,2, Usman N.Y.1,2, Arutyunyan I.V.1,2, Makarov A.V.1,2,3, Bykov A.V.3, Bolshakova G.V.2, Sukhikh G.T.1
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Affiliations:
- V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Institute of Human Morphology
- N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 161, No 1 (2016)
- Pages: 155-161
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/237220
- DOI: https://doi.org/10.1007/s10517-016-3367-5
- ID: 237220
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Abstract
In the liver of rats subjected to subtotal liver resection (80% organ weight), the expression of sox9 gene and SOX9 protein content increased and cells with hepatocyte morphology expressing SOX9 appeared; the proportion of cells expressing cytokeratin-19 also increased. Based on these data, we cannot completely exclude the involvement of resident progenitor cells and hepatocyte reprogramming in liver regeneration after subtotal resection, however, the contribution of these processes seems to be insignificant. The leading mechanism of liver mass recovery after subtotal resection is proliferation of hepatocytes.
About the authors
A. V. El’chaninov
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Institute of Human Morphology; N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation
Email: fatkhudinov@gmail.com
Russian Federation, Moscow; Moscow; Moscow
T. Kh. Fatkhudinov
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Institute of Human Morphology; N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: fatkhudinov@gmail.com
Russian Federation, Moscow; Moscow; Moscow
E. Yu. Kananykhina
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Institute of Human Morphology
Email: fatkhudinov@gmail.com
Russian Federation, Moscow; Moscow
N. Yu. Usman
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Institute of Human Morphology
Email: fatkhudinov@gmail.com
Russian Federation, Moscow; Moscow
I. V. Arutyunyan
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Institute of Human Morphology
Email: fatkhudinov@gmail.com
Russian Federation, Moscow; Moscow
A. V. Makarov
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation; Institute of Human Morphology; N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation
Email: fatkhudinov@gmail.com
Russian Federation, Moscow; Moscow; Moscow
A. V. Bykov
N. I. Pirogov Russian State Medical University, Ministry of Health of the Russian Federation
Email: fatkhudinov@gmail.com
Russian Federation, Moscow
G. V. Bolshakova
Institute of Human Morphology
Email: fatkhudinov@gmail.com
Russian Federation, Moscow
G. T. Sukhikh
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: fatkhudinov@gmail.com
Russian Federation, Moscow
