Maintenance of High Cytochrome P450 Expression in HepaRG Cell Spheroids in DMSO-Free Medium

A. V. Aleksandrova; O. A. Burmistrova; K. A. Fomicheva; D. A. Sakharov

doi:10.1007/s10517-016-3360-z

Maintenance of High Cytochrome P450 Expression in HepaRG Cell Spheroids in DMSO-Free Medium

作者: Aleksandrova A.V.¹, Burmistrova O.A.¹, Fomicheva K.A.², Sakharov D.A.¹^,3
隶属关系:
1. BioClinicum Research and Production Center
2. National Medical Research Radiology Center
3. Moscow State University of Mechanical Engineering (MAMI)
期: 卷 161, 编号 1 (2016)
页面: 120-124
栏目: Article
URL: https://journals.rcsi.science/0007-4888/article/view/237180
DOI: https://doi.org/10.1007/s10517-016-3360-z
ID: 237180

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详细

We studied the effects of DMSO and fibroblasts during HepaRG cell spheroid formation and conditions of their subsequent culturing on the levels of mRNA of the major cytochromes P450. A protocol of spheroid formation from differentiated HepaRG cells and their culturing in serum- and DMSO-free medium is developed.