Email this article Studying the Effect of a Composition of the Cluster Core in High-Radiopacity Cluster Complexes of Rhenium on Their Acute Toxicity In Vivo
- Authors: Pozmogova T.N.1,2, Krasil’nikova A.A.1,3,2, Ivanov A.A.3,2, Shestopalov M.A.3,2,4, Gyrylova S.N.3, Shestopalova L.V.1, Shestopaloiv A.M.3, Shkurupy V.A.3
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Affiliations:
- Novosibirsk State University
- Research Institute of Clinical and Experimental Lymphology
- Research Institute of Experimental and Clinical Medicine
- A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences
- Issue: Vol 161, No 1 (2016)
- Pages: 64-68
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237102
- DOI: https://doi.org/10.1007/s10517-016-3346-x
- ID: 237102
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Abstract
An in vivo study was performed to evaluate the dependence of acute toxicity of high-radiopacity and luminescent octahedral cluster complexes of rhenium after intravenous injection on a composition of the cluster core. Changes in mouse body weight, water and food consumption, degree of intoxication, and morphological changes in the visceral organs were studied after intravenous injection of the following cluster complexes with various internal ligands (S, Se, or Te): Na4[{Re6Te8}(CN)6], Na4[{Re6Se8}(CN)6], and Na4[{Re6S8}(CN)6]. The Na4[{Re6S8} (CN)6] cluster complex was shown to be the safest for animals.
About the authors
T. N. Pozmogova
Novosibirsk State University; Research Institute of Clinical and Experimental Lymphology
Email: shestopalov2@ngs.ru
Russian Federation, Novosibirsk; Novosibirsk
A. A. Krasil’nikova
Novosibirsk State University; Research Institute of Experimental and Clinical Medicine; Research Institute of Clinical and Experimental Lymphology
Email: shestopalov2@ngs.ru
Russian Federation, Novosibirsk; Novosibirsk; Novosibirsk
A. A. Ivanov
Research Institute of Experimental and Clinical Medicine; Research Institute of Clinical and Experimental Lymphology
Email: shestopalov2@ngs.ru
Russian Federation, Novosibirsk; Novosibirsk
M. A. Shestopalov
Research Institute of Experimental and Clinical Medicine; Research Institute of Clinical and Experimental Lymphology; A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences
Author for correspondence.
Email: shestopalov2@ngs.ru
Russian Federation, Novosibirsk; Novosibirsk; Novosibirsk
S. N. Gyrylova
Research Institute of Experimental and Clinical Medicine
Email: shestopalov2@ngs.ru
Russian Federation, Novosibirsk
L. V. Shestopalova
Novosibirsk State University
Email: shestopalov2@ngs.ru
Russian Federation, Novosibirsk
A. M. Shestopaloiv
Research Institute of Experimental and Clinical Medicine
Email: shestopalov2@ngs.ru
Russian Federation, Novosibirsk
V. A. Shkurupy
Research Institute of Experimental and Clinical Medicine
Email: shestopalov2@ngs.ru
Russian Federation, Novosibirsk
