Studying the Effect of a Composition of the Cluster Core in High-Radiopacity Cluster Complexes of Rhenium on Their Acute Toxicity In Vivo

Resumo

An in vivo study was performed to evaluate the dependence of acute toxicity of high-radiopacity and luminescent octahedral cluster complexes of rhenium after intravenous injection on a composition of the cluster core. Changes in mouse body weight, water and food consumption, degree of intoxication, and morphological changes in the visceral organs were studied after intravenous injection of the following cluster complexes with various internal ligands (S, Se, or Te): Na₄[{Re₆Te₈}(CN)₆], Na₄[{Re₆Se₈}(CN)₆], and Na₄[{Re₆S₈}(CN)₆]. The Na₄[{Re₆S₈} (CN)₆] cluster complex was shown to be the safest for animals.