Role of L1CAM in the Regulation of the Canonical Wnt Pathway and Class I MAGE Genes

M. Yu. Shkurnikov; E. N. Knyazev; D. Wicklein; U. Schumacher; T. R. Samatov; A. G. Tonevitskii

doi:10.1007/s10517-016-3315-4

Role of L1CAM in the Regulation of the Canonical Wnt Pathway and Class I MAGE Genes

Authors: Shkurnikov M.Y.¹, Knyazev E.N.¹, Wicklein D.², Schumacher U.², Samatov T.R.³, Tonevitskii A.G.¹
Affiliations:
1. National Medical Research Radiological Center, Ministry of Health of the Russian Federation
2. University Medical-Center Hamburg-Eppendorf
3. Moscow State University of Mechanical Engineering (MAMI)
Issue: Vol 160, No 6 (2016)
Pages: 807-810
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/236959
DOI: https://doi.org/10.1007/s10517-016-3315-4
ID: 236959

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Abstract
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Abstract

Molecule L1CAM is specific for nerve cells and tumors of various localizations. The expression of L1CAM is significantly higher in melanoma in comparison with benign nevi and correlates with the progress of melanoma and transition from radial to vertical growth. Monoclonal antibodies to L1CAM effectively and specifically attenuate melanoma growth, though stimulates the epithelial–mesenchymal transition. shRNA-mediated knock-down of L1CAM showed the involvement of L1CAM in regulation of activity of the canonical Wnt pathway and expression of genes of class I melanoma-associated antigens (MAGE).

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Role of L1CAM in the Regulation of the Canonical Wnt Pathway and Class I MAGE Genes

Full Text

Abstract

About the authors

M. Yu. Shkurnikov

E. N. Knyazev

D. Wicklein

U. Schumacher

T. R. Samatov

A. G. Tonevitskii

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