Role of L1CAM in the Regulation of the Canonical Wnt Pathway and Class I MAGE Genes
- 作者: Shkurnikov M.1, Knyazev E.1, Wicklein D.2, Schumacher U.2, Samatov T.3, Tonevitskii A.1
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隶属关系:
- National Medical Research Radiological Center, Ministry of Health of the Russian Federation
- University Medical-Center Hamburg-Eppendorf
- Moscow State University of Mechanical Engineering (MAMI)
- 期: 卷 160, 编号 6 (2016)
- 页面: 807-810
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236959
- DOI: https://doi.org/10.1007/s10517-016-3315-4
- ID: 236959
如何引用文章
详细
Molecule L1CAM is specific for nerve cells and tumors of various localizations. The expression of L1CAM is significantly higher in melanoma in comparison with benign nevi and correlates with the progress of melanoma and transition from radial to vertical growth. Monoclonal antibodies to L1CAM effectively and specifically attenuate melanoma growth, though stimulates the epithelial–mesenchymal transition. shRNA-mediated knock-down of L1CAM showed the involvement of L1CAM in regulation of activity of the canonical Wnt pathway and expression of genes of class I melanoma-associated antigens (MAGE).
作者简介
M. Shkurnikov
National Medical Research Radiological Center, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: mshkurnikov@imscs.msu.ru
俄罗斯联邦, Moscow
E. Knyazev
National Medical Research Radiological Center, Ministry of Health of the Russian Federation
Email: mshkurnikov@imscs.msu.ru
俄罗斯联邦, Moscow
D. Wicklein
University Medical-Center Hamburg-Eppendorf
Email: mshkurnikov@imscs.msu.ru
德国, Hamburg
U. Schumacher
University Medical-Center Hamburg-Eppendorf
Email: mshkurnikov@imscs.msu.ru
德国, Hamburg
T. Samatov
Moscow State University of Mechanical Engineering (MAMI)
Email: mshkurnikov@imscs.msu.ru
俄罗斯联邦, Moscow
A. Tonevitskii
National Medical Research Radiological Center, Ministry of Health of the Russian Federation
Email: mshkurnikov@imscs.msu.ru
俄罗斯联邦, Moscow
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