Effect of Target Therapy on the Content of Transcription and Growth Factors, Protein Kinase TOR, and Activity of Intracellular Proteases in Patients with Metastatic Renal Cell Carcinoma
- Authors: Spirina L.V.1, Usynin E.A.1, Kondakova I.V.1, Yurmazov Z.A.1, Slonimskaya E.M.1
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Affiliations:
- Tomsk Research Institute of Cancer
- Issue: Vol 160, No 6 (2016)
- Pages: 798-801
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/236953
- DOI: https://doi.org/10.1007/s10517-016-3313-6
- ID: 236953
Cite item
Abstract
We analyzed the dynamics of the expression of transcription factors, VEGF and its receptor VEGFR2, serine-threonine protein kinase mTOR and activity of proteasome and calpain in patients with metastatic renal cancer during therapy with tyrosine kinase inhibitor Votrient and mTOR blocker Afinitor. The expression of hypoxic nuclear factor HIF-1α in the tumor tissue decreased during therapy with the target preparations. The decrease of VEGF and its receptor VEGFR2 was observed only in patients treated with mTOR inhibitor. The increase in calpain activity in the tumor tissue was observed in both groups. These findings extend our understanding of the mechanism of action of target anticancer preparations as allow considering the studied markers as predictors in choosing optimal therapy.
About the authors
L. V. Spirina
Tomsk Research Institute of Cancer
Author for correspondence.
Email: spirinalvl@mail.ru
Russian Federation, Tomsk
E. A. Usynin
Tomsk Research Institute of Cancer
Email: spirinalvl@mail.ru
Russian Federation, Tomsk
I. V. Kondakova
Tomsk Research Institute of Cancer
Email: spirinalvl@mail.ru
Russian Federation, Tomsk
Z. A. Yurmazov
Tomsk Research Institute of Cancer
Email: spirinalvl@mail.ru
Russian Federation, Tomsk
E. M. Slonimskaya
Tomsk Research Institute of Cancer
Email: spirinalvl@mail.ru
Russian Federation, Tomsk
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