Effect of Target Therapy on the Content of Transcription and Growth Factors, Protein Kinase TOR, and Activity of Intracellular Proteases in Patients with Metastatic Renal Cell Carcinoma
- 作者: Spirina L.1, Usynin E.1, Kondakova I.1, Yurmazov Z.1, Slonimskaya E.1
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隶属关系:
- Tomsk Research Institute of Cancer
- 期: 卷 160, 编号 6 (2016)
- 页面: 798-801
- 栏目: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/236953
- DOI: https://doi.org/10.1007/s10517-016-3313-6
- ID: 236953
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详细
We analyzed the dynamics of the expression of transcription factors, VEGF and its receptor VEGFR2, serine-threonine protein kinase mTOR and activity of proteasome and calpain in patients with metastatic renal cancer during therapy with tyrosine kinase inhibitor Votrient and mTOR blocker Afinitor. The expression of hypoxic nuclear factor HIF-1α in the tumor tissue decreased during therapy with the target preparations. The decrease of VEGF and its receptor VEGFR2 was observed only in patients treated with mTOR inhibitor. The increase in calpain activity in the tumor tissue was observed in both groups. These findings extend our understanding of the mechanism of action of target anticancer preparations as allow considering the studied markers as predictors in choosing optimal therapy.
作者简介
L. Spirina
Tomsk Research Institute of Cancer
编辑信件的主要联系方式.
Email: spirinalvl@mail.ru
俄罗斯联邦, Tomsk
E. Usynin
Tomsk Research Institute of Cancer
Email: spirinalvl@mail.ru
俄罗斯联邦, Tomsk
I. Kondakova
Tomsk Research Institute of Cancer
Email: spirinalvl@mail.ru
俄罗斯联邦, Tomsk
Z. Yurmazov
Tomsk Research Institute of Cancer
Email: spirinalvl@mail.ru
俄罗斯联邦, Tomsk
E. Slonimskaya
Tomsk Research Institute of Cancer
Email: spirinalvl@mail.ru
俄罗斯联邦, Tomsk
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