Effects of Selective Agonists of V1a, V2, and V1b Receptors on Sodium Transport in Rat Kidney

Abstract

The role of subtypes of vasopressin receptors in modulation of renal sodium reabsorption was studied in in vivo experiments on Wistar rats. Selective V_1a receptor agonist reduced sodium reabsorption in the kidneys and expression of these receptors increased by practically 100 times. This effect was similar to the effect of furosemide. Selective V₂ receptor agonist enhanced sodium reabsorption in the kidney and simultaneously increased reabsorption of solute-free water. Stimulation of V_1b receptors did not affect sodium transport. Our findings attest to the key role of V_1a receptors in the regulation of renal excretion of sodium ions.