Mechanisms of Erythropoietin–Stimulating Action of Anti-Erythropoietin Release-Active Antibodies in Complex Treatment of Experimental Anemia during Gestation
- Authors: Burmina Y.V.1, Udut E.V.1, Zhdanov V.V.1, Sotnikova L.S.1, Miroshnichenko L.A.1, Simanina E.V.1, Polyakova T.Y.1, Zyuz’kov G.N.1, Chaikovskii A.V.1, Stavrova L.A.1, Epshtein O.I.1, Dygai A.M.1
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Affiliations:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Issue: Vol 160, No 6 (2016)
- Pages: 737-741
- Section: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/236923
- DOI: https://doi.org/10.1007/s10517-016-3298-1
- ID: 236923
Cite item
Abstract
We studied the mechanisms of erythropoiesis stimulation and effectiveness of Poetam, a preparation containing release-active anti-erythropoietin antibodies as a supplement treatment for experimental iron deficiency anemia during gestation. The results confirmed potency of combined therapy to stimulate erythropoiesis, which was more efficacious in comparison with monotherapy as assessed by the count of erythrokaryocytes and erythroid progenitors in the hematopoietic tissue as well as by the content of erythrocytes and hemoglobin in the peripheral blood. Activation of erythropoiesis is related to the modulatory effect of Poetam on proliferative activity and differentiation of erythroid precursors, which in most aspects results from stimulatory action of Poetam on secretion of the hematopoietically active factors by adherent elements of the hematopoietic microenvironment.
About the authors
Ya. V. Burmina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Russian Federation, Tomsk
E. V. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Author for correspondence.
Email: evu8@mail.ru
Russian Federation, Tomsk
V. V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Russian Federation, Tomsk
L. S. Sotnikova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Russian Federation, Tomsk
L. A. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Russian Federation, Tomsk
E. V. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Russian Federation, Tomsk
T. Yu. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Russian Federation, Tomsk
G. N. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Russian Federation, Tomsk
A. V. Chaikovskii
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Russian Federation, Tomsk
L. A. Stavrova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Russian Federation, Tomsk
O. I. Epshtein
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Russian Federation, Tomsk
A. M. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Russian Federation, Tomsk