Mechanisms of Erythropoietin–Stimulating Action of Anti-Erythropoietin Release-Active Antibodies in Complex Treatment of Experimental Anemia during Gestation
- Авторлар: Burmina Y.1, Udut E.1, Zhdanov V.1, Sotnikova L.1, Miroshnichenko L.1, Simanina E.1, Polyakova T.1, Zyuz’kov G.1, Chaikovskii A.1, Stavrova L.1, Epshtein O.1, Dygai A.1
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Мекемелер:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Шығарылым: Том 160, № 6 (2016)
- Беттер: 737-741
- Бөлім: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/236923
- DOI: https://doi.org/10.1007/s10517-016-3298-1
- ID: 236923
Дәйексөз келтіру
Аннотация
We studied the mechanisms of erythropoiesis stimulation and effectiveness of Poetam, a preparation containing release-active anti-erythropoietin antibodies as a supplement treatment for experimental iron deficiency anemia during gestation. The results confirmed potency of combined therapy to stimulate erythropoiesis, which was more efficacious in comparison with monotherapy as assessed by the count of erythrokaryocytes and erythroid progenitors in the hematopoietic tissue as well as by the content of erythrocytes and hemoglobin in the peripheral blood. Activation of erythropoiesis is related to the modulatory effect of Poetam on proliferative activity and differentiation of erythroid precursors, which in most aspects results from stimulatory action of Poetam on secretion of the hematopoietically active factors by adherent elements of the hematopoietic microenvironment.
Авторлар туралы
Ya. Burmina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
E. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Хат алмасуға жауапты Автор.
Email: evu8@mail.ru
Ресей, Tomsk
V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
L. Sotnikova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
L. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
E. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
T. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
G. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
A. Chaikovskii
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
L. Stavrova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
O. Epshtein
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
A. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: evu8@mail.ru
Ресей, Tomsk
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