Отправить статью по E-mail Detection and Characteristics of Rifampicin-Resistant Isolates of Mycobacterium tuberculosis
- Авторы: Cherednichenko A.G.1, Dymova M.A.2,3, Solodilova O.A.4, Petrenko T.I.1, Prozorov A.I.4, Filipenko M.L.2,3
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Учреждения:
- Research Institute of Tuberculosis, Ministry of Health of the Russian Federation
- Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
- Novosibirsk State University
- Altai Regional Antituberculous Dispensary
- Выпуск: Том 160, № 5 (2016)
- Страницы: 659-663
- Раздел: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/236868
- DOI: https://doi.org/10.1007/s10517-016-3243-3
- ID: 236868
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Аннотация
Genotyping and analysis the drug resistance of 59 isolates of M. tuberculosis obtained from patients living in Altai Territory were performed using a BACTEC MGIT 960 fluorometric system by means of VNTR typing (variable number tandem repeat), PCR-RFLP analysis, and sequence analysis. The occurrence frequency was highest for isolates of the Beijing family (n=30, 50.8%). Analysis of mutation spectrum in the rpoB gene associated with rifampicin resistance revealed the major mutation (codon 531 of the rpoB gene) in 93% samples, which allows us to use rapid test systems.
Об авторах
A. Cherednichenko
Research Institute of Tuberculosis, Ministry of Health of the Russian Federation
Email: maya.a.rot@gmail.com
Россия, Novosibirsk
M. Dymova
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences; Novosibirsk State University
Автор, ответственный за переписку.
Email: maya.a.rot@gmail.com
Россия, Novosibirsk; Novosibirsk
O. Solodilova
Altai Regional Antituberculous Dispensary
Email: maya.a.rot@gmail.com
Россия, Barnaul
T. Petrenko
Research Institute of Tuberculosis, Ministry of Health of the Russian Federation
Email: maya.a.rot@gmail.com
Россия, Novosibirsk
A. Prozorov
Altai Regional Antituberculous Dispensary
Email: maya.a.rot@gmail.com
Россия, Barnaul
M. Filipenko
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences; Novosibirsk State University
Email: maya.a.rot@gmail.com
Россия, Novosibirsk; Novosibirsk
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