Transplantation of Simian Mesenchymal Stem Cells to Baboons with Experimentally Induced Myocardial Infarction

V. Z. Agrba; V. A. Porkhanov; D. D. Karal-ogly; A. V. Leontyuk; A. L. Kovalenko; I. Yu. Sholin; T. E. Gvozdik; I. E. Ignatova; A. A. Agumava; Yu. P. Chuguev; I. A. Gvaramiya; B. A. Lapin

doi:10.1007/s10517-016-3223-7

Transplantation of Simian Mesenchymal Stem Cells to Baboons with Experimentally Induced Myocardial Infarction

Authors: Agrba V.Z.¹, Porkhanov V.A.¹, Karal-ogly D.D.¹, Leontyuk A.V.¹, Kovalenko A.L.¹, Sholin I.Y.¹, Gvozdik T.E.¹, Ignatova I.E.¹, Agumava A.A.¹, Chuguev Y.P.¹, Gvaramiya I.A.¹, Lapin B.A.¹
Affiliations:
1. Research Institute of Medical Primatology
Issue: Vol 160, No 4 (2016)
Pages: 589-591
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/236821
DOI: https://doi.org/10.1007/s10517-016-3223-7
ID: 236821

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Abstract

Culture of mesenchymal stem cells isolated from the bone marrow of primates by their characteristics met the requirements of stem cells. It was shown that transplantation of allogeneic mesenchymal stem cells (2 million cells per 1 kg body weight) immediately after ligation of the left anterior descending coronary artery between the middle and upper thirds led to neovascularization and capillarization of the ischemic myocardium.