Possibility of Using Mesenchymal Stromal Cells to Restore Lymph Flow in Experimental Phlebothrombosis
- Authors: Maiborodin I.V.1, Morozov V.V.1, Matveeva V.A.1, Chastikin G.A.1, Moshak S.V.1, Onoprienko N.V.1, Seryapina Y.V.1, Anikeev A.A.1
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Affiliations:
- Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 160, No 4 (2016)
- Pages: 565-570
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236793
- DOI: https://doi.org/10.1007/s10517-016-3219-3
- ID: 236793
Cite item
Abstract
The possibility of formation of lymphatic vessels after introduction of autologous bone marrow-derived multipotent mesenchymal stromal cells transfected with GFP gene into thrombosed femoral vein was studied by fluorescent microscopy. Vascular thrombosis caused by ligation of the great vein with subsequent injection of thrombin solution was accompanied by blockade of regional lymph flow. The cells injected into thrombosed vein directly participate in the formation of new lymphatic vessels in the paravasal tissue surrounding the vein, its tissue region, and around regional lymph nodes. This is seen from bright specific fluorescence of individual cells in the walls of lymphatic vessels and all vascular layers and valves in UV light.
About the authors
I. V. Maiborodin
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: imai@mail.ru
Russian Federation, Novosibirsk
V. V. Morozov
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Russian Federation, Novosibirsk
V. A. Matveeva
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Russian Federation, Novosibirsk
G. A. Chastikin
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Russian Federation, Novosibirsk
S. V. Moshak
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Russian Federation, Novosibirsk
N. V. Onoprienko
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Russian Federation, Novosibirsk
Yu. V. Seryapina
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Russian Federation, Novosibirsk
A. A. Anikeev
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
Russian Federation, Novosibirsk