Possibility of Using Mesenchymal Stromal Cells to Restore Lymph Flow in Experimental Phlebothrombosis
- 作者: Maiborodin I.1, Morozov V.1, Matveeva V.1, Chastikin G.1, Moshak S.1, Onoprienko N.1, Seryapina Y.1, Anikeev A.1
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隶属关系:
- Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
- 期: 卷 160, 编号 4 (2016)
- 页面: 565-570
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236793
- DOI: https://doi.org/10.1007/s10517-016-3219-3
- ID: 236793
如何引用文章
详细
The possibility of formation of lymphatic vessels after introduction of autologous bone marrow-derived multipotent mesenchymal stromal cells transfected with GFP gene into thrombosed femoral vein was studied by fluorescent microscopy. Vascular thrombosis caused by ligation of the great vein with subsequent injection of thrombin solution was accompanied by blockade of regional lymph flow. The cells injected into thrombosed vein directly participate in the formation of new lymphatic vessels in the paravasal tissue surrounding the vein, its tissue region, and around regional lymph nodes. This is seen from bright specific fluorescence of individual cells in the walls of lymphatic vessels and all vascular layers and valves in UV light.
作者简介
I. Maiborodin
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
V. Morozov
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
V. Matveeva
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
G. Chastikin
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
S. Moshak
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
N. Onoprienko
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
Yu. Seryapina
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
A. Anikeev
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk