Simulation of Viral Hepatitis E in Marmosets

K. K. Kyuregyan; V. F. Poleshchuk; I. V. Gordeichuk; T. V. Gulyaeva; O. V. Isaeva; I. A. Morozov; M. I. Mikhailov

doi:10.1007/s10517-016-3173-0

Simulation of Viral Hepatitis E in Marmosets

Authors: Kyuregyan K.K.¹, Poleshchuk V.F.¹, Gordeichuk I.V.¹, Gulyaeva T.V.¹, Isaeva O.V.¹, Morozov I.A.¹, Mikhailov M.I.¹
Affiliations:
1. M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences
Issue: Vol 160, No 3 (2016)
Pages: 368-371
Section: Primatology
URL: https://journals.rcsi.science/0007-4888/article/view/236709
DOI: https://doi.org/10.1007/s10517-016-3173-0
ID: 236709

Cite item

Full Text

Open Access
Restricted Access

Access granted
Restricted Access

Subscription Access

Abstract
About the authors
References
Statistics

Abstract

We developed a model of hepatitis E virus infection in common marmosets (Callithrix jacchus) and determined optimal route of infection, duration, clinical and virological characteristics of infection in laboratory animals. Using this model, we demonstrated that replication of hepatitis E virus primarily occurs in the liver, while virus replication presumed to take place in the intestine was not confirmed in this experiment.