Simulation of Viral Hepatitis E in Marmosets

K. K. Kyuregyan; V. F. Poleshchuk; I. V. Gordeichuk; T. V. Gulyaeva; O. V. Isaeva; I. A. Morozov; M. I. Mikhailov

doi:10.1007/s10517-016-3173-0

Simulation of Viral Hepatitis E in Marmosets

Autores: Kyuregyan K.¹, Poleshchuk V.¹, Gordeichuk I.¹, Gulyaeva T.¹, Isaeva O.¹, Morozov I.¹, Mikhailov M.¹
Afiliações:
1. M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences
Edição: Volume 160, Nº 3 (2016)
Páginas: 368-371
Seção: Primatology
URL: https://journals.rcsi.science/0007-4888/article/view/236709
DOI: https://doi.org/10.1007/s10517-016-3173-0
ID: 236709

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We developed a model of hepatitis E virus infection in common marmosets (Callithrix jacchus) and determined optimal route of infection, duration, clinical and virological characteristics of infection in laboratory animals. Using this model, we demonstrated that replication of hepatitis E virus primarily occurs in the liver, while virus replication presumed to take place in the intestine was not confirmed in this experiment.