Email this article Short Peptides and Telomere Length Regulator Hormone Irisin
- Authors: Khavinson V.K.1,2, Kuznik B.I.3, Tarnovskaya S.I.2,4, Lin’kova N.S.2,4
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Affiliations:
- Russian Academy of Sciences, I. P. Pavlov Institute of Physiology
- St. Petersburg Institute of Bioregulation and Gerontology
- Chita State Medical Academy, Ministry of Health of the Russian Federation
- St. Petersburg State Polytechnological University
- Issue: Vol 160, No 3 (2016)
- Pages: 347-349
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236703
- DOI: https://doi.org/10.1007/s10517-016-3167-y
- ID: 236703
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Abstract
Irisin produced by muscles during exercise and promoting fat burning also exhibits geroprotective effect and induces telomere elongation in normal somatic cells. Special attention is paid to studies of the role of peptides Lys-Glu, Glu-Asp-Arg, and Ala-Glu-Asp-Gly in epigenetic regulation of irisin content. The data suggest that the immunomodulatory peptide Lys-Glu and neuroprotective peptide Glu-Asp-Arg modulate the life span by modulating irisin gene expression.
About the authors
V. Kh. Khavinson
Russian Academy of Sciences, I. P. Pavlov Institute of Physiology; St. Petersburg Institute of Bioregulation and Gerontology
Email: linkova@gerontology.ru
Russian Federation, Moskva; St. Petersburg
B. I. Kuznik
Chita State Medical Academy, Ministry of Health of the Russian Federation
Email: linkova@gerontology.ru
Russian Federation, Chita
S. I. Tarnovskaya
St. Petersburg Institute of Bioregulation and Gerontology; St. Petersburg State Polytechnological University
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg; St. Petersburg
N. S. Lin’kova
St. Petersburg Institute of Bioregulation and Gerontology; St. Petersburg State Polytechnological University
Author for correspondence.
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg; St. Petersburg
