Email this article Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205
- Authors: Spasov A.A.1, Kalitin K.Y.1, Grechko O.Y.1, Anisimova V.A.1
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Affiliations:
- Volgograd State Medical University
- Issue: Vol 160, No 3 (2016)
- Pages: 336-339
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236700
- DOI: https://doi.org/10.1007/s10517-016-3164-1
- ID: 236700
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Abstract
Antiepileptic activity of a new derivative of benzimidazole RU-1205 was studied on the model of pentylenetetrazole-induced generalized seizures in mice. Sodium valproate was used as the reference substance. RU-1205 was superior to sodium valproate by anticonvulsant activity (by 12 times) and therapeutic index (by 8.5 times). In contrast to sodium valproate, RU-1205 exhibited significant anticonvulsant activity on the model of pentylenetetrazole-induced kindling without tendency to resistance development.
About the authors
A. A. Spasov
Volgograd State Medical University
Email: kkonst8@yandex.ru
Russian Federation, Volgograd
K. Yu. Kalitin
Volgograd State Medical University
Author for correspondence.
Email: kkonst8@yandex.ru
Russian Federation, Volgograd
O. Yu. Grechko
Volgograd State Medical University
Email: kkonst8@yandex.ru
Russian Federation, Volgograd
V. A. Anisimova
Volgograd State Medical University
Email: kkonst8@yandex.ru
Russian Federation, Volgograd
