Enviar artigo por via de e-mail Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205
- Autores: Spasov A.1, Kalitin K.1, Grechko O.1, Anisimova V.1
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Afiliações:
- Volgograd State Medical University
- Edição: Volume 160, Nº 3 (2016)
- Páginas: 336-339
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236700
- DOI: https://doi.org/10.1007/s10517-016-3164-1
- ID: 236700
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Resumo
Antiepileptic activity of a new derivative of benzimidazole RU-1205 was studied on the model of pentylenetetrazole-induced generalized seizures in mice. Sodium valproate was used as the reference substance. RU-1205 was superior to sodium valproate by anticonvulsant activity (by 12 times) and therapeutic index (by 8.5 times). In contrast to sodium valproate, RU-1205 exhibited significant anticonvulsant activity on the model of pentylenetetrazole-induced kindling without tendency to resistance development.
Sobre autores
A. Spasov
Volgograd State Medical University
Email: kkonst8@yandex.ru
Rússia, Volgograd
K. Kalitin
Volgograd State Medical University
Autor responsável pela correspondência
Email: kkonst8@yandex.ru
Rússia, Volgograd
O. Grechko
Volgograd State Medical University
Email: kkonst8@yandex.ru
Rússia, Volgograd
V. Anisimova
Volgograd State Medical University
Email: kkonst8@yandex.ru
Rússia, Volgograd
