Email this article Effect of Annexin V on Development of Apoptosis in Placental Syncytiotrophoblast Nuclei during Exacerbation of Cytomegalovirus Infection in the Third Trimester
- Authors: Lutsenko M.T.1, Andrievskaya I.A.1
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Affiliations:
- Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences
- Issue: Vol 160, No 3 (2016)
- Pages: 327-329
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236698
- DOI: https://doi.org/10.1007/s10517-016-3162-3
- ID: 236698
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Abstract
During exacerbation of cytomegalovirus infection during pregnancy, cytomegalovirus proteins penetrate across the external membrane of placental villous syncytiotrophoblast and suppress activities of ATPase and Bcl-2 protein. Simultaneous increase in the content of annexin V and caspase 3 leads to structural disturbances in DNA in syncytiotrophoblast nuclei and stimulates their apoptosis. Structural abnormalities in the syncytiotrophoblast during exacerbation of cytomegalovirus infection are dangerous for fetal development.
About the authors
M. T. Lutsenko
Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences
Author for correspondence.
Email: lucenkomt@mail.ru
Russian Federation, Blagoveshchensk
I. A. Andrievskaya
Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences
Email: lucenkomt@mail.ru
Russian Federation, Blagoveshchensk
