The Sensitivity of Human Tumor Cells to the Cytotoxicity of Gold Polyacrylate (Aurumacryl)

D. B. Korman; E. I. Nekrasova; L. A. Ostrovskaya; O. O. Ryabaya; N. V. Bluhterova; K. A. Abzaeva

doi:10.1134/S0006350919060125

The Sensitivity of Human Tumor Cells to the Cytotoxicity of Gold Polyacrylate (Aurumacryl)

Авторлар: Korman D.B.¹, Nekrasova E.I.¹, Ostrovskaya L.A.¹, Ryabaya O.O.², Bluhterova N.V.¹, Abzaeva K.A.³
Мекемелер:
1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
2. Blokhin National Medical Research Center for Oncology, Ministry of Health of the Russian Federation
3. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
Шығарылым: Том 64, № 6 (2019)
Беттер: 930-935
Бөлім: Cell Biophysics
URL: https://journals.rcsi.science/0006-3509/article/view/153148
DOI: https://doi.org/10.1134/S0006350919060125
ID: 153148

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат
Рұқсат жабық

Рұқсат берілді
Рұқсат жабық

Тек жазылушылар үшін

Аннотация
Авторлар туралы
Әдебиет тізімі
Қосымша файлдар
Статистика

Аннотация

The cytotoxic effect of the antitumor drug aurumacryl (gold polyacrylate) against human tumor cells of various origins has been studied. It has been shown that aurumacryl exhibits significant cytotoxic activity against cells of lung carcinoma А549 (IC₅₀ = 60 μg/mL), melanoma Mel-mо (IC₅₀ = 80 μg/mL), and breast carcinoma MCF-7 (IC₅₀ = 90 μg/mL), while being substantially less efficient against colon carcinoma НСТ116 cells (IC₅₀ = 180 μg/mL).